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Researchers use neurotypical volunteers to calibrate MRI machines across sites and remove the machine-introduced noise. Suddenly structural differences in ADHD brains, which were being masked by the noise, become clearer to see. newatlas.com/adhd-autism/adhd-…
in reply to Sarah Brown

It is quite a problem to calibrate the physical responses of the different machines to a common standard, and then calibrate all the inversion software to produce consistent results.
in reply to Sarah Brown

be careful with your assumptions. So far the history of MRI studies linked to psychology or personality, is littered with greater diversity within the class of interest or controls, than the mean difference. Whilst reducing the noise will reduce the in group diversity, hence increase the 'significance' of any parameter difference, the categorisation of people by an MRI remains unwise, it certainly should not be used for diagnosis.
Humans are nonergodic, hence diagnose the person!