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Needle-Free: New Nano-Vaccine Effective Against All COVID-19 Variants

(Administered as intranasal spray, stable at room temperature, broad spectrum. No word on whether/when it'll be available.)

scitechdaily.com/needle-free-nโ€ฆ

in reply to Charlie Stross

And some nasal spray vaccine candidates provide sterilizing immunity: the virus is killed before it enters your system, rather than just being a milder case.
in reply to Charlie Stross

@Charlie Stross Oh nice! Had two Covid vaccines this year. Had Covid last week donโ€™t want this to happen again.
in reply to Charlie Stross

"As good as Pfizer" isn't that good. Certainly not a prospect of a sterilizing vaccine, which we may not be able to get against a coronavirus.

The generality (all the variants), the logistics (it costs less and you can keep dosing people quarterly), and the prospect of the technique extending are to my mind the more interesting things here.

in reply to Cobweb ๐Ÿ‚

@cobweb Load it into cropduster tanks and spray it over cities inhabited by anti-vaxxers and chemtrail conspiracy theorists!
in reply to Charlie Stross

@cobweb Claiming that this is being done might actually get the fuckers to mask up!

Charlie Stross reshared this.

in reply to Feรฒrag

@feorag @cobweb And we can start claiming it right now. These fuckers are going to believe anything as long as it's not true.
in reply to Sarah Brown

Or just explain how the drones seen all over the US are spraying the vaccine, and how it will remain active for at least 48 hours after they've seen a drone (this of course why Trump is asking to shoot them).
With some luck, they'll refuse to breathe while there is "danger".
This entry was edited (1 week ago)
in reply to Charlie Stross

@cobweb As described, that'd work!

You could probably mist it into shared airspaces via something indistinguishable from a humidifier rather more economically.

Charlie Stross reshared this.

in reply to Graydon

@graydon @cobweb As @feorag notes, we should *tell* the conspiracy theorists it's in the chemtrails! That way they'll suddenly see sense (FSVO "sense") and start masking up.
in reply to Charlie Stross

@cobweb @feorag It's a vivid mental image but if they believed in chemtrails as material things they'd be in respirators with organic vapour cartridges already.

Humans build community through shared meals, sure, but also through shared complex lies. This can be TTRPGs, fan fiction, fan activity around nearly anything, and so on. One of those things is "conspiracy theories"; the point is not that you believe it (though you don't not believe it), it's that you're helping tell the story.

in reply to Charlie Stross

@cobweb This is some choice, premium irony right here. I'm just going to savor it for a while before looking up the location of Elon's jet and bolting a suspicious-looking sprayer tank on, if it ever gets close.
in reply to Charlie Stross

@cobweb How about adding it to plug in air fresheners so anyone who comes for Christmas is automatically vaxxed up?
in reply to Charlie Stross

Hopefully it will work better than the highly touted and not so great 'Flu-mist'
I know they are using it in some cases, but it never replaced the shot in the arm flu vaccine.
One can only help
in reply to Charlie Stross

Oh please oh pleaseโ€ฆ

Of course I wonโ€™t be able to afford it, but still.

in reply to Charlie Stross

Yay! And more new vaccines on the way.

I hope we won't have to leave the #USA to get them under the insanity of the Trump RFK antiscience government dismantling.

absolutelymaybe.plos.org/2024/โ€ฆ #Covid19

Wilfried Klaebe reshared this.

in reply to Charlie Stross

they better get it out as fast, and as cheap, as possible instead of just being another vapourware drug
in reply to Ko Simon C. Hulse toku ingoa

@SimonCHulse It's showing promise in testing ... on mice. Needs three phases of human clinical trials before it's demonstrated to be safe *and* efficacious. A lot of meds never make it past that hurdle: we've had credible anti-AIDS vaccines for decadesโ€”but only in mice (they failed in humans).
in reply to Bobsee

@Bobsee Trump is a user. He will use Bobby Kennedy until he becomes a liability, then dump him on the spot. (And if not Trump, then whoever is pulling the strings.) The trouble is, Trump's first instinct in the face of a pandemic is to monetize itโ€”remember him peddling Ivermectin in 2020?
in reply to Charlie Stross

im a little late to this one, but i really hope it works. nasal vaccines have been really troublesome for adverse events and have often died in phase 1 or 2, but it would be so great if we could get one of these working -- putting the immunity *where* the infection happens in a big fucking deal for stopping it, not just reacting to the infection. fingers crossed!
in reply to Quinn Norton

@quinn Meanwhile, over in the Excited Snakes of Amurrica, RFK Jr's best buddy is trying to get FDA approval for the fricken' *polio vaccine* withdrawn.

I swear I despair of humanity.

in reply to Charlie Stross

I know the evil is powerful, charlie, but i believe the FDA's endless bureaucracy and glacial pace will defeat all its enemies, including itself.
in reply to Quinn Norton

As for new drugs, and indications... well i'm glad a moved to the EU ๐Ÿ˜ฌ
in reply to Quinn Norton

@quinn Yes but, fricken' RFK Jr! In charge of public health! In a country that's got an agricultural sector that seems to be TRYING to generate a human-viable H5N1 flu strain! (Incoherent screaming)
in reply to Charlie Stross

we gotta take this timeline one day at a time, man. โค๏ธ ๐Ÿ˜‚
in reply to Charlie Stross

@quinn indeed. You are aware that RFK jr makes his money selling snake oil? This incompetent bunch is bent on profiteering while retaining expensive remedies for themselves.
in reply to Charlie Stross

we hope that these vaccines will offer a path to less isolation, and they will be approved soon, but with incoming admin, rather unlikely now.
in reply to Charlie Stross

One thing thatโ€™s not mentioned in the article is whether itโ€™s a live vaccine or not. Most intra-nasal vaccines so far are live. Live vaccines are very effective, but you canโ€™t give them to immunocompromised people.
in reply to Shouty person

@clacksee It's definitely not a live vaccine. Details in the articleโ€”it's peptide sequences from the virus coat protein embedded in a synthetic nanoparticle.
in reply to Shouty person

@clacksee It is, however, only a runaway success in mice (so far). Needs to start human trials some time, which is where about 95% of promising drugs in development fall over.
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