Am reconnecting with the trans community a bit and have discovered that the new thing GICs are doing to torment trans women, having moved on from RLE, is keeping them on starvation rations of HRT.
@Alda Vigdís 🇵🇸 🇱🇧 @Riley S. Faelan I crossed that bridge some time ago. Most of them are just mechanics, and a lot of them are not even very good at that.
@Alda Vigdís 🇵🇸 🇱🇧 @Riley S. Faelan @Sarah Brown I'm on 1.5mg of sandrena a day which a chart I just found under a rock says is equivalent to 3mg progynova. (Though ahem sometimes I just take two whole sachets because I feel like it.). 0.75mg seems... kinda homeopathic?
Actually, going to keep this chart because whenever I want to look up equivalent doses I can never find the data. chiark.greenend.org.uk/~ajlane…
to be fair CX left me on 2mg Progynova a day. They agreed to up it when Barrett declared me "undercooked". My GP refused. Every so often, I've pushed but don't get anywhere. Once the new job is sorted, I'll look into working a private dose on top of prescribed
@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in
... show more
@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in this case, counted as the amount contained in the gel. It diffuses through the skin relatively fast, but not all of it reaches the blood.
(For order-of-magnitude context, a typical target level might be about 500 pmol/l. A mole of estradiol weighs about 270 grammes, and a woman might, on the bigger side, contain about five litres of blood, so all that target estradiol in her blood adds up to some 0.7 microgrammes; at a time, anyway.)
This is fascinating. The Arabic words for minute (as in 1/60 hr) and second (as in 1/60 min) are the same as the words for minute (as in very small) and second (ordinal number 2). And English, it seems, got it from the Arabs via Medieval Latin.
Same in Hebrew, unsurprisingly I suppose. דק/דקה and שני/שניה, which are cognate to the Arabic words. I'm not sure whether Hebrew got it from Arabic or whether they both got it from common Semitic roots, though.
@Colin Watson The suggestion from that Wikipedia article (which I’ve not researched further so may be total bobbins) is that it’s from the flourishing of science in the Islamic world, although that’s a world that’s always had Jews in so 🤷♀️
I can easily believe it's of Arabic origin due to sheer numbers of mediaeval scientists. Just wondered, as Wiktionary's etymology wasn't clear either way
@Juliet E McKenna Probably didn't have to cope with OU word limits! (Just took a quick look at In Verrem. Quite pleased to find that I can still make out a fair bit of it in spite of my last properly using Latin three decades ago!)
It is more than a single sentence, much, much more. It is a gateway to another world: an abstract world of symbols and relationships. It is a single thread of Inrda's net, interfused with reflecting jewels, containing within it ripples of the whole history of symbolic thought.
Nay! [always a good word in situations like this]. Verily! [even better] I put it to you, [forgot this was a law assignment for a moment] your worships and honours, taking into account the principle of totality [adjusts headgear] that indeed, no sentence can ever be singular.
Interesting observation. When talking one-to-one to a woman I don't know well my brain flips into the before-transition mode, where I'm hyper-aware I pose a threat.
@zoe I'm really curious. Is it just Portugal, US, Canada and Mexico that use corks for wine? We use screw tops in Aotearoa New Zealand. My memory is that Switzerland uses screw tops.
And … the book never specified which silo she ended up in, but it’s obvious now from that little artefact reveal that it’s 18.
Simms’ wife … can stay in the vault. She’s … oh shit!
That’s REALLY clever. I wonder if that’s Howey kicking himself for not doing that in the first place?
So S3 is Shift, and I guess we don’t return to 18 until the start of S4, or once enough of Shift has happened to make it into dramatic irony (I.e. the audience knows the secret but the characters don’t).
I fricking LOVE them putting Helen in 18. Love it!
tha k you for the warning. I don't get to see this until 9 o'clock tonight. I have seen others mention things throughout the week. Does the show release on earlier days outside the US?
@Natasha Jay 🇪🇺 It's not in the book, but note that right at the end of S02E10, Donald gives the Pez dispenser to Helen. She's one of the founders of Silo 18.
You are NOT supposed to know that. They’ve changed something from the books (I mean they’ve changed quite a lot, but that’s a biggie. 51 is on the need to know list, and the head of IT isn’t on it)
@Natasha Jay 🇪🇺 @Katy Swain You could absolutely make a Shift spinoff just with the late 21st century Donald and Paul stuff, let alone the rest of it.
I’m guessing they aren’t going to do the alternative back and forth between the near future and the silos that Shift does.
And then there’s the question of the reveals. You have to reveal what the big bad is before you reveal WHY. The glimpse at the end of S2 looks like it could portray Paul Thurman in a much more … I hesitate to say sympathetic light, but maybe an understandable one? Perhaps we’ll agree with him that something drastic had to be done to save humanity.
But, you know, there’s drastic and then there’s murdering everyone except half a million people who you decide to imprison in a bunch of deep holes for centuries.
@Natasha Jay 🇪🇺 @Katy Swain I want to be made uncomfortable and conflicted about what I’d do in Paul Thurman’s position. If it manages that, then it will be some of the best sci-fi ever.
Ok, so the tunnel isn’t in the books, but I can kinda guess where it goes.
The voice which spoke to Lukas though. I initially assumed it’s Donald, but maybe not. Maybe someone finding the tunnel is what makes them go and wake Thurman up?
@andy piercing the skin to let fat out (since that's strongly concentrated near the skin) Also stabbing it to test if it's cooked or not. Raw meat will leak pink fluid, cooked meat will leak clear.
I seem to remember there was somewhere off the coast of Norfolk or Suffolk at some point where new mothers went to register their births as it was unparished, so they didn't have to acknowledge the father. The memory is a bit of a muddle, but I can't find any reference to it.
Feeling proud of myself. I contacted a therapist who should be able to help me with my fun new anxiety issues, and also started some work on them on my own, of which I may say more at a later date.
So you're speaking a sentence in Portuguese, are you? Well you have 0.5 seconds to decide between a subordinating conjunction or a preposition/naked adjective, AND IT WILL DETERMINE THE COURSE OF THE REST OF YOUR LIFE!
And before the “but not everyone is dead” comments, it’s absolutely canon that the only humans alive are under Fulton County, Georgia. Howey has said so himself, and the plot makes no sense if they’re not.
If you drink a massive amount of Gin&Tonic, you might use up a quarter of them. Squeeze the rest over freshly cooked fish - it is good in Portugal (unless to are veggi).
After having covid in December and a horrible new year cold (family brought that one in), my immune system has taken a beating and I keep getting zits and it’s pissing me off.
Sarah Brown
Unknown parent • •Alexandra Lanes
Unknown parent • •@Alda Vigdís 🇵🇸 🇱🇧 @Riley S. Faelan @Sarah Brown I'm on 1.5mg of sandrena a day which a chart I just found under a rock says is equivalent to 3mg progynova. (Though ahem sometimes I just take two whole sachets because I feel like it.). 0.75mg seems... kinda homeopathic?
Actually, going to keep this chart because whenever I want to look up equivalent doses I can never find the data. chiark.greenend.org.uk/~ajlane…
Sarah Brown
in reply to Alexandra Lanes • •Nikkileah 🎮🚄🏳️⚧️🇬🇧
in reply to Sarah Brown • • •Once the new job is sorted, I'll look into working a private dose on top of prescribed
Sarah Brown
in reply to Nikkileah 🎮🚄🏳️⚧️🇬🇧 • •Alexandra Lanes
in reply to Sarah Brown • •Alexandra Lanes
Unknown parent • •Alexandra Lanes
in reply to Alexandra Lanes • •Riley S. Faelan
Unknown parent • • •@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in
... show more@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in this case, counted as the amount contained in the gel. It diffuses through the skin relatively fast, but not all of it reaches the blood.
(For order-of-magnitude context, a typical target level might be about 500 pmol/l. A mole of estradiol weighs about 270 grammes, and a woman might, on the bigger side, contain about five litres of blood, so all that target estradiol in her blood adds up to some 0.7 microgrammes; at a time, anyway.)
@goatsarah
Riley S. Faelan
in reply to Riley S. Faelan • • •@alda Sorry.
It turned out grumpier than I meant to.
I've not been having a good day.
@goatsarah