Trying to explain amphetamine sleepiness to medics and they’re like, “that’s just tolerance allowing you to sleep on it”
And like, it’s not “allowing”. It’s like being shot with a sedative dart. It is more sedating than diazepam for me.
Given I have boosters, there are multiple nap danger zones during the day. It’s not every time, but when it happens … goodnight. You nap now. No, it isn’t a choice. Sleep.
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These are stuck. I’ve manually deleted them from the database but they come back after a few days.
Is there some sort of timeout setting I can use?
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This is not a subtweet. I promise it’s not. It’s just something that occurred to me as a really useful analogy for so many situations, so I’m sharing it:
Yelling at the tsunami alarm to shut up won’t stop you drowning. Get off the fucking beach.
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I spotted that “citalopram chiq” was in while shopping in a Lisboa mall a couple of weeks ago. Not a single thing that wasn’t “I need SSRIs because INGSOC runs the world now”
And here’s Next getting in on the act.
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So sometimes it’s clear that my serum amphetamine baseline can start to get away from me. 3 days ago it was clear I’d fallen off the wrong side of the curve because the ADHD had got squashed so hard that I went very very very autistic. Like struggling to communicate with people at all autistic. It was very distressing.
So two days ago I let it wash out and took my regular Elvanse dose at 4pm, electing to not take the Amfexa booster at all. This equates to about a 40% dose reduction in daily dextro amphetamine intake.
Yesterday, on returning to the normal dose my Elvanse felt … somewhat ineffective but after I took the booster I was really feeling it.
Today about an hour after taking my Elvanse (Elvanse is Lisdexamphetamine which converts to amphetamine in the blood. It gives it a delayed release profile), at the point at which it hit, I started giggling uncontrollably. This lasted a couple of minutes.
And then my head is clear as a bell.
Back in the room, I guess.
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Been a while with iOS 27 now. Supposedly the great bug fix release.
If possible it’s buggier than 26. Some keyboard stuff has been fixed but there are new bugs that weren’t there before.
Apple has forgotten how to write software.
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No, pip; I am pretty sure I do not need to create a virtual environment INSIDE A SODDING DOCKER CONTAINER.
STFU with your bullshit.
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What a lovely view.
Backdrop is quite nice too.
(If you know, you know)
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Hear me out here: what if you added l-lysine dimesylate to the amino group on pseudoephedrine?
You could call it Vyfed and spin some bullshit about how it doing nothing for an hour and depleting your protein reserves is good actually.
Right. Patent office. I am very smart.
I see Apple have made a 3000 euro phone that you can’t protect against being dropped.
I’ll pass
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Oh. I like how nobody is asking the obvious question.
About Bernard.
I expect they’ll get to that.
They changed the Silo 17 thing around a bit. I get why. In the books you were kinda left to work out the precise details of what actually happened out there right at the start. It was very heavily implied but never spelled out.
And I saw some people who read it and then completely missed the central point of WHY they were down there.
I suspect they’re gonna lay it on a bit more thickly here. Perhaps Troy will do some helpful exposition?
Assuming he works it out for himself. I assume he knows how the people sent out to clean die. No reason he wouldn’t.
Temperance movement: We want to reduce alcohol consumption!
Me: I went from 3 bottles of wine a week to nothing with no relapses after 18 months and no desire to relapse.
Temperance movement: Holy shit! Amazing! Please share how you did it!
Me: You’re gonna really hate this bit …
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Yes, I am fucking judging you.
Shitbags
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Silo S0309
Ok. Different conceit to the book, but the big bad cat is now out of the bag.
It’s gonna get more fucked up. A lot.
Also I LOVE how much fan service/lamp shading there was in that ep;
“We could use a drone pilot” - TOO SOON
“Why would they need to kill a silo?”
The lift. Jesus Christ. If silo 1 found out about that … instant safeguard.
Bullet hole in very dangerous outside air mysteriously doesn’t kill when poor seals in the cleaning suits do.
I preferred the digger subplot in the book tho. The rationale worked much better.
Perfect end of season reveal would be switching to the “the voice”’s point of view as he utters those three words that he said to Lukas Kyle in the second book.
I think we’re gonna see the pez dispenser again.
I had been taking it for granted that internal servers need IPv4 addresses.
But these days lots of them … don’t.
They just don’t.
Am increasingly experimenting with IPv6-only (as in no v4 capability at all), and it largely just works.
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Was assuming methylphenidate was “different” until I looked harder.
Oh
I see what you did there.
Just give me the red bit and we’re good.
FWIW, I'm pretty sure Elvanse's duration is dose-dependent. My last uptitration step was mostly to make sure that my evenings would be reliably covered when I take it in the morning.
AFAIU, its pharmacokinetic curve has three main components: the cleavage of the lysine dimesylate, which probably typically takes just one to two hours; the exponential decay curve of renal clearance after the amphetamine has become free in blood and gotten stocked up by the synapses, and some sort of effectiveness threshold. The exponential decay curve interacts with the effectiveness threshold in ways that are non-linear and can be non-intuitive to one who hasn't dabbled in calculus. But both components vary between people.
This kind of sounds like your metabolism causes rapid swings, and the effectiveness threshold might be on the low side. Do you happen to know if taking, say, 30mg in the morning and 30mg in the aftrnoon, before the first dose runs out, might produce a friendlier curve in you?
Blood pressure of ADHD people going down on amphetamine is pretty common, AFAIK. The NT explanation is, it's because treating the ADHD reduces stress, but I kind of suspect that, at least in some forms of ADHD, the "paradoxical" effect of stimulants is directly applicable, kind of similarly to how RightHormones often directly improve a trans person's brain functions and happiness.
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@Riley S. Faelan Yeah. It's definitely not due to lower stress. I *HAVE* lower stress, but different stimulants affect me differently in terms of blood pressure.
Caffeine - mild effect on ADHD, blood pressure goes up.
Amphetamine - huge effect on ADHD, blood pressure goes "standing up is now FAFO"
Ephedrine - effect on ADHD comparable to caffeine. Blood pressure *craters*
That last one must utterly piss off anaesthetists.
I've tried splitting my Elvanse dose. It just weakens the first one and the second one does piss all. Elvanse 30 contains more dexamphetamine (eventually) than Amfexa 10 but the latter gives me 3 - 3 1/2 good hours and the former gives me 2 hours of "meh" (both after 70mg of Elvanse).
The whole "stimulants do the same in ADHD and non ADHD people once you account for the different baseline" thing is such obvious bullshit, brought to you by the same people responsible for such classics as "Only boys get this", "Only children get this", "This is never comorbid with autism", and, "emotional disregulation is not a symptom".
@Riley S. Faelan Yeah, tell me about it. I've tried it and it made me long for the sweet sweet release of death.
Dex or GTFO
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The real answer to those people is, “It doesn’t matter what you think you can tell. If you make a high priority of ruining the lives of people who are just trying to live in peace, you’re a monster and a loser.”
The only person who has a right to ask about someone’s A_AB status is a potential sexual partner.
You’re quite pretty, too. But that’s not relevant to your (valid) point, or mine. Not that you should care about the opinion of J. Random Guy (of a similar age).
Seeing Thurman take Daniel and Helen to see the construction site brings a whole new meaning to “the devil went down to Georgia”
Not sure what to make of the “billionaire secretly funds whole enterprise” thing. I guess it feels more in tune with our time but I liked the way it happened in the book: “we’re building a nuclear waste storage site. Nothing to see here. Just nuclear waste. Honest. It’s certainly not a ‘murdering the entire human race and chucking the survivors in 50 deep holes for 500 years thing’. Oh. Was that the out loud voice?”
I reckon I know what the end of S3 cliffhanger thingy is going to be. S1 and S2 departed from Wool quite a bit but S3 is taking Shift and completely scrambling it.
Wondering if Troy is going to give Mrs Simms the same line he gave Lukas Kyle in the book about how they all ended up down there?
Mate, I’m in the EU. You can’t just go advertising Billy at me.
Anyway, I’ve got dexies.
Possibly the biggest single hive of whining cunts on the Internet.
“Hello. I would like my partner to be someone else, but they aren’t, so I’m going to try and traumatise them into it”.
Have you considered the multiple benefits of “fucking off”?
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Happy birthday, Michael O'Leary
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Warner Bros says the flagship store will be inspired by magical Diagon Alley and open on 4 November.Jess Warren (BBC News)
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Silo mild spoilers
OMG, Thurman is gonna tell them.
That's ... not how to went down in the book. Donald(Daniel) got played.
Unless she's still going with the pretend reason for building the silos.
@FoolishOwl So not gonna spoil you, but the memory drug subplot was someone else in the books and because of other narrative changes they can't do that in the same way.
But I'm pretty sure I figured out how they're going to do it.
The internet: Every part of the ephedra plant contains ephedrine, pseudoephedrine, and methylephidrine which cause hypertension in humans and is therefore toxic.
Also the internet: Mormons harvested ephedra and made an infusion from it because they weren’t allowed caffeine. This is called Mormon tea.
Me: makes Mormon tea from harvested ephedra fragilis stems
Also me: hypertension. Good talk. Right.
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A disabled boat being towed into a marina we were in ourselves 2 months ago makes the orca situation very real.
They attacked a second boat in the same place. It sank. Everyone is alive.
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@Raimondas Lapinskas 🌍 Yes. This is an excellent reply to alluding to how fucking terrified I am of being attacked by the giant murder dolphins. Good talk.
Wanker
Latest Silo: Well THAT wasn't in the books.
Also, Troy, stop being such a knobhead.
@The Drop Bear 2.0 Yeah. The constant threats to murder 10,000 people are rude and make him seem like an asshole.
Ok, he's complicit in murdering billions, but ... well you know what I mean. There were circumstances.
@Natasha 🇪🇺🇮🇪 @mark Same, and I'm only enjoying it more having read the books.
I wonder how many people who haven't have spotted the thing with Troy? It's obvious if you know to look for it.
@mark They've changed quite a lot.
Irrelevant stuff is things like Daniel was called Donald in the books, and they gender swapped Senator Thurman
Seasons 1&2 had some significant departures. The entire Simms plot line isn't in there. They don't know about the digger void. And some other stuff.
But this season is MASSIVELY different from Shift (book 2). It kinda had to be because unless the change really is radical as all hell, there's a reveal they need to do which simply would not work if you can see the characters as it was written.
So I'm interested to know where they're going with it.
Oh, and the flashback 21st century story is MASSIVELY different in the book, although the nature of the threat is the same, more or less.
Recent security patches from Apple and, I believe, others, have clamped down on accessing what are thought to be non local services on LAN, or something along those lines.
Which is utterly screwing my homeland stuff because it uses IPv6 and has globally routable addresses. Because it’s IPv6. And that’s how it works.
I have spent AGES trying to find the “bug” in my network config when there isn’t one.
Works if I access via Wireguard.
I am reduced to using a VPN to access my network. On my network.
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@Dr. Sobek Big fan of many substituted phenethylamines here.
But that one in particular.
That isomer too.
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MJ Ray
in reply to Sarah Brown • • •Sarah Brown
in reply to MJ Ray • •@MJ Ray It's not quite that bad but yeah, it feels like benzodiazepine sedation.
"You are going to lie down and close your eyes. This is not optional"
MJ Ray
in reply to Sarah Brown • • •Sarah Brown
in reply to MJ Ray • •@MJ Ray I mean, naps
Naps are the solution