I am CIS but I cannot understand this illogical trans hatred. I guess it is like racism and hate a minority to stir the rabble but totally utterly baseless. I wouldn’t have known you were trans without you telling me. Makes no difference, two happy women enjoying themselves
Am reconnecting with the trans community a bit and have discovered that the new thing GICs are doing to torment trans women, having moved on from RLE, is keeping them on starvation rations of HRT.
@Alda Vigdís 🇵🇸 🇱🇧 @Riley S. Faelan @Sarah Brown I'm on 1.5mg of sandrena a day which a chart I just found under a rock says is equivalent to 3mg progynova. (Though ahem sometimes I just take two whole sachets because I feel like it.). 0.75mg seems... kinda homeopathic?
Actually, going to keep this chart because whenever I want to look up equivalent doses I can never find the data. chiark.greenend.org.uk/~ajlane…
@ajlanes That's a really useful chart, thank you! (bookmarks)
I seem to be gathering a lot of anecdata about patches not being as effective. Swtiching to transdermal from 2mg, at last test I was still under half target figures on a mixture of a 100 patch, one estrogel dose and one Lenzetto dose, after the patch alone was practically useless.
to be fair CX left me on 2mg Progynova a day. They agreed to up it when Barrett declared me "undercooked". My GP refused. Every so often, I've pushed but don't get anywhere. Once the new job is sorted, I'll look into working a private dose on top of prescribed
@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in
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@alda That's not a good way to quantify "dermal" estrogen. Its bioavailability is very different in transdermal gel form and in transdermal patch form, for one, and common application frequencies differ, too.
Patches are virtually universally rated not in the amount of the effective ingredient that they contain (although it's documented, and can be important for War On Drugs purposes when the ingredient is a controlled substance), but the amount of the ingredient that they release. The ones I have had experience with release either 50 or 100 microgrammes per day, and last for four days (nominally half a week, but weeks have an odd number of days in them). A patch might contain, say, a whopping eight milligrammes of estradiol in it, but most of it will remain in the matrix by the time the diffusion efficiency will have dropped to a pint that one should replace the patch.
A typical transdermal gel dosage is about a milligramme of estradiol, in this case, counted as the amount contained in the gel. It diffuses through the skin relatively fast, but not all of it reaches the blood.
(For order-of-magnitude context, a typical target level might be about 500 pmol/l. A mole of estradiol weighs about 270 grammes, and a woman might, on the bigger side, contain about five litres of blood, so all that target estradiol in her blood adds up to some 0.7 microgrammes; at a time, anyway.)
@zoe I'm really curious. Is it just Portugal, US, Canada and Mexico that use corks for wine? We use screw tops in Aotearoa New Zealand. My memory is that Switzerland uses screw tops.
And … the book never specified which silo she ended up in, but it’s obvious now from that little artefact reveal that it’s 18.
Simms’ wife … can stay in the vault. She’s … oh shit!
That’s REALLY clever. I wonder if that’s Howey kicking himself for not doing that in the first place?
So S3 is Shift, and I guess we don’t return to 18 until the start of S4, or once enough of Shift has happened to make it into dramatic irony (I.e. the audience knows the secret but the characters don’t).
I fricking LOVE them putting Helen in 18. Love it!
tha k you for the warning. I don't get to see this until 9 o'clock tonight. I have seen others mention things throughout the week. Does the show release on earlier days outside the US?
@Natasha Jay 🇪🇺 It's not in the book, but note that right at the end of S02E10, Donald gives the Pez dispenser to Helen. She's one of the founders of Silo 18.
You are NOT supposed to know that. They’ve changed something from the books (I mean they’ve changed quite a lot, but that’s a biggie. 51 is on the need to know list, and the head of IT isn’t on it)
@Natasha Jay 🇪🇺 @Katy Swain You could absolutely make a Shift spinoff just with the late 21st century Donald and Paul stuff, let alone the rest of it.
I’m guessing they aren’t going to do the alternative back and forth between the near future and the silos that Shift does.
And then there’s the question of the reveals. You have to reveal what the big bad is before you reveal WHY. The glimpse at the end of S2 looks like it could portray Paul Thurman in a much more … I hesitate to say sympathetic light, but maybe an understandable one? Perhaps we’ll agree with him that something drastic had to be done to save humanity.
But, you know, there’s drastic and then there’s murdering everyone except half a million people who you decide to imprison in a bunch of deep holes for centuries.
@Natasha Jay 🇪🇺 @Katy Swain I want to be made uncomfortable and conflicted about what I’d do in Paul Thurman’s position. If it manages that, then it will be some of the best sci-fi ever.
Ok, so the tunnel isn’t in the books, but I can kinda guess where it goes.
The voice which spoke to Lukas though. I initially assumed it’s Donald, but maybe not. Maybe someone finding the tunnel is what makes them go and wake Thurman up?
@andy piercing the skin to let fat out (since that's strongly concentrated near the skin) Also stabbing it to test if it's cooked or not. Raw meat will leak pink fluid, cooked meat will leak clear.
So you're speaking a sentence in Portuguese, are you? Well you have 0.5 seconds to decide between a subordinating conjunction or a preposition/naked adjective, AND IT WILL DETERMINE THE COURSE OF THE REST OF YOUR LIFE!
And before the “but not everyone is dead” comments, it’s absolutely canon that the only humans alive are under Fulton County, Georgia. Howey has said so himself, and the plot makes no sense if they’re not.
If you drink a massive amount of Gin&Tonic, you might use up a quarter of them. Squeeze the rest over freshly cooked fish - it is good in Portugal (unless to are veggi).
After having covid in December and a horrible new year cold (family brought that one in), my immune system has taken a beating and I keep getting zits and it’s pissing me off.
Hi @Sarah Brown. As you may already know from some of my posts I'm a Unitarian Universalist. I'm also an atheist. At First Universalist Parish in Derby Line, Vermont we fly both the Black Lives Matter and Pride flag. Members of the trans community will typically find a welcoming space in most UU congregations. My former faith of Jehovah's Witnesses, makes no room for such individuals. They would be disfellowshipped and shunned for simply being who they are. Fortunately liberal religions exist and I'd say in this moment we will be challenged to raise to the moment to do what we can to help. Take care, -Randy
It is frigtning. Unfortunately I’ve been through this before. I remember sitting over from lawyers talking through what to do about my partner who had been fired on the spot for being trans. Or dealing with scum in a super market who has decided to hassle me badly. I learnt quickly that you fight back. In that case security and management supported me because I was a regular who did their weekly shop there. But yes prior to the EA2010 and prior to the GRA2004 and prior to the ECHR rulings you had the SDA and “good people” and there are a lot more of them than you think. The scumbags are few just vocal!
Update: After this blog post was written, we learned Meta revised its public "Hateful Conduct" policy in ways EFF finds concerning. We are analyzing these changes, which this blog post does not address.
@eff the EFF would always protect a Nazi's right to maximally spew hate over a trans person's right to exist. See their pearl clutching about Kiwi Farms not getting kicked by their DDoS protection service.
Thanks for this post @Sarah Brown. I don't follow that many details around Facebook & Meta. Seems almost certain that anti-trans groups and individuals will feel more bold in the days ahead especially after Donald Trump assumes the Presidency. I am working on a sermon for next Sunday titled The Wisdom Of No Escape and the Path of Loving-Kindness. I hope those in attendance find some comfort and hope even as things begin be more bleak. With kind regards, -Randy
@grayface_ghost One of the reasons I left FB was because they kept undoing my privacy settings. I don't know if they still do that but I have zero trust in them.
Estarriol, Terrorist Dragon
in reply to Sarah Brown • • •Lazarou Monkey Terror 🚀💙🌈
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